As I leave my old position and start a new position I hand wrote thank you notes to several individuals. A couple have commented specifically on them. The clearest sign that my investment of time was worth while was the impression it made on one colleague who said that when she opened what was clearly a card her initial reaction was "a hand written note!" In this day and age it is surprising, but somehow people perceive it as a different level of thought and effort. I suppose in my case, particularly to make it legible. I don't know how many more hand written notes I will send in the near future, but an old school approach apparently can sometimes make a big difference to people.